Chaperoning heterochromatin: new roles of FACT in chromatin silencing

The multitasking histone chaperone FACT (FAcilitates Chromatin Transcription) contributes to actively transcribed euchromatin and repressed heterochromatin. However, its precise role in gene silencing has remained obscure. Here, we discuss new insights into the silent chromatin functions and recruitment mechanisms of FACT, and their possible implications in cell identity and cancer.

Automated summary

This article discusses new insights into the role and recruitment mechanisms of the multitasking histone chaperone FACT in gene silencing, and its potential implications in cell identity and cancer.