期刊
TRENDS IN GENETICS
卷 38, 期 3, 页码 290-304出版社
CELL PRESS
DOI: 10.1016/j.tig.2021.08.016
关键词
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资金
- Canadian Institutes of Health Research [299429, 388041]
- Canada Research Chairs [950-230661]
The maintenance of genome stability and cellular homeostasis relies on the coordination of DNA damage response (DDR) with other cellular processes. This review examines the crosstalk between DNA repair factors, chromatin remodeling, replication, transcription, genome organization, cytoskeletal forces, and liquid-liquid phase separation (LLPS) in mediating DNA repair. The authors present an overarching DNA repair framework that incorporates these dynamic processes in the nucleus.
The maintenance of genome stability and cellular homeostasis depends on the temporal and spatial coordination of successive events constituting the classical DNA damage response (DDR). Recent findings suggest close integration and coordination of DDR signaling with specific cellular processes. The mechanisms underlying such coordination remain unclear. We review emerging crosstalk between DNA repair factors, chromatin remodeling, replication, transcription, spatial genome organization, cytoskeletal forces, and liquid-liquid phase separation (LLPS) in mediating DNA repair. We present an overarching DNA repair framework within which these dynamic processes intersect in nuclear space overtime. Collectively, this interplay ensures the efficient assembly of DNA repair proteins onto shifting genome structures to preserve genome stability and cell survival.
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