Cell type-specific chromatin topology and gene regulation

Chromatin structure is critically involved in gene regulation and cell fate determination. How this structure is established and maintained in distinct, terminally differentiated cells remains elusive. Winick-Ng et al. address this puzzle by applying immunoGAM in different brain cell types and reveal cell type-specific chromatin topologies, long gene decompaction, and the involvement of transcription factors (TFs).

Automated summary

In this study, Winick-Ng et al. used immunoGAM to investigate chromatin structure in different brain cell types, revealing cell type-specific chromatin topologies, long gene decompaction, and the involvement of transcription factors.