Does chromatin function as a metabolite reservoir?

Alternative histone acylations integrate gene expression with cellular metabolic states. Recent measurements of cellular acylcoenzyme A (acyl-CoA) pools highlight the potential that histone post-translational modifications (PTMs) contribute directly to the regulation of metabolite pools. A metabolite-centric view throws new light onto roles and evolution of histone PTMs.

Automated summary

This article discusses the relationship between histone post-translational modifications (PTMs) and cellular metabolic states, emphasizing the potential role of metabolite information in understanding the functions and evolution of histone PTMs.