期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 47, 期 3, 页码 250-264出版社
CELL PRESS
DOI: 10.1016/j.tibs.2021.11.004
关键词
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资金
- National Key R&D Program of China [2019YFA0802600, 2018YFC1004500]
- National Natural Science Foundation of China [31725016, 31930019, 91940303, 32070633]
- Strategic Priority Research Program 'Biological Basis of Aging and Therapeutic Strategies' of the Chinese Academy of Sciences [XDB39010400]
- Fundamental Research Funds for the Central Universities of China [2021CDJZYJH-002, 2020CDJQY-A076]
- Natural Science Foundation of Chongqing China [cstc2019jcyjmsxmX0085]
- Innovation Support Program for Overseas Returned Scholars of Chongqing China [cx2019142]
Circular RNAs (circRNAs) are covalently closed single-stranded RNAs with unique features in their biogenesis, degradation, and transport. They have diverse molecular functions, including sponging miRNAs, regulating transcription, modulating RNA-binding proteins, and even encoding proteins. Dysregulation of circRNAs is associated with various human disorders. Further research can help resolve debates and potentially lead to biomedical applications of circRNAs.
Circular RNAs (circRNAs) are covalently closed single-stranded RNAs. Four subclasses of circRNAs have been identified in animal cells, and they have unique features in their biogenesis, degradation, and transport. CircRNAs have diverse molecular functions in sponging miRNAs, regulating transcription, modulating RNA-binding proteins, and even encoding proteins. Some circRNAs are important regulators of various physiological processes to maintain homeostasis. Dysregulation of circRNAs is associated with human disorders, and individual circRNAs are crucial factors that contribute to major diseases including non-immunological diseases such as cancers, neurological disorders, cardiovascular disease, and metabolic disease. Debates on circRNAs have also been raised in recent years, and further studies would help to resolve these disputes and potentially lead to biomedical applications of circRNAs.
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