期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 47, 期 3, 页码 235-249出版社
CELL PRESS
DOI: 10.1016/j.tibs.2021.10.008
关键词
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资金
- BBSRC [BB/N01524X/1, BB/T015853/1]
- UCLA Specialty Training and Advanced Research (STAR) fellowship program
- NIH [T32HL007895]
- [NIH-GM088790]
- [NSF-2027748]
- [R15-GM131329]
- BBSRC [BB/T015853/1] Funding Source: UKRI
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca2+ from endosomes and lysosomes by activating two-pore channels (TPCs). Two different NAADP-binding proteins (NAADP-BPs), JPT2 and LSM12, have recently been identified, bridging the gap between NAADP generation and NAADP activation of TPCs. The discovery of these NAADP-BPs will facilitate future studies on the molecular mechanism of NAADP action.
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca2+ from endosomes and lysosomes by activating ion channels called two-pore channels (TPCs). However, no NAADP-binding site has been identified on TPCs. Rather, NAADP activates TPCs indirectly by engaging NAADP-binding proteins (NAADP-BPs) that form part of the TPC complex. After a decade of searching, two different NAADP-BPs were recently identified: Jupiter microtubule associated homolog 2 (JPT2) and like-Sm protein 12 (LSM12). These discoveries bridge the gap between NAADP generation and NAADP activation of TPCs, providing new opportunity to understand and manipulate the NAADP-signaling pathway. The unmasking of these NAADP-BPs will catalyze future studies to define the molecular choreography of NAADP action.
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