期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 47, 期 5, 页码 403-416出版社
CELL PRESS
DOI: 10.1016/j.tibs.2022.01.001
关键词
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资金
- National Institute of General Medical Sciences [R35 GM119840]
- National Institute of Mental Health of the National Institutes of Health (NIH) [R01 MH122142]
- National Science Foundation [DGE-1746045]
Noncovalent interactions play a crucial role in cellular processes, and by taking inspiration from natural systems, we can design directed evolution platforms to generate proteins that bind to specific biomolecules. Recent advancements have expanded the range of interactions that can be evolved.
Noncovalent interactions between biomolecules such as proteins and nucleic acids coordinate all cellular processes through changes in proximity. Tools that perturb these interactions are and will continue to be highly valuable for basic and translational scientific endeavors. By taking cues from natural systems, such as the adaptive immune system, we can design directed evolution platforms that can generate proteins that bind to biomolecules of interest. In recent years, the platforms used to direct the evolution of biomolecular binders have greatly expanded the range of types of interactions one can evolve. Herein, we review recent advances in methods to evolve protein-protein, protein-RNA, and protein-DNA interactions.
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