期刊
CANCER INVESTIGATION
卷 33, 期 3, 页码 78-85出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2014.1001894
关键词
Cell-free circulating nucleic acids; Prognosis; Pancreatic cancer
类别
资金
- Indian Council of Medical Research (ICMR), New Delhi
- Department of Biotechnology (DBT), New Delhi
Pancreatic cancer is a highly aggressive disease with rapid invasion and early encasement of blood vessels. Hence, levels of circulating nucleic acids and tumor-associated mutations in them may have clinical importance. We analyzed the levels of circulating tumor DNA and oncogenic k-ras mutation in plasma of patients with pancreatic cancer and correlated their levels with survival and clinicopathological parameters. Higher levels of plasma DNA (> 62 ng/mL) was found to associate significantly with lower overall survival time (p = .002), presence of vascular encasement (p = .030) and metastasis (p = .001). However, k-ras mutation status did not correlate with any of the clinicopathological parameters or survival. We conclude that circulating DNA in plasma can be an important predictor of prognosis in pancreatic cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据