A Fourth Dose of COVID-19 Vaccine Does Not Induce Neutralization of the Omicron Variant Among Solid Organ Transplant Recipients With Suboptimal Vaccine Response

Article Surgery

Insufficient response to mRNA SARS-CoV-2 vaccine and high incidence of severe COVID-19 in kidney transplant recipients during pandemic

Tomas Reischig et al.

Summary: This study found that the protection of SARS-CoV-2 mRNA vaccination against COVID-19 is limited in kidney transplant recipients, with some patients developing COVID-19 after vaccination having lower levels of anti-spike protein IgG. While some patients were able to produce higher IgG levels after COVID-19, overall humoral responses were not significant, leading to suboptimal efficacy post-vaccination.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Surgery

A third dose of SARS-CoV-2 vaccine increases neutralizing antibodies against variants of concern in solid organ transplant recipients

Andrew H. Karaba et al.

Summary: Vaccine-induced antibody responses are weaker in solid organ transplant recipients (SOTRs), and breakthrough infections are more common. Additional vaccine doses increase antibody levels in some SOTRs, but the neutralization capacity is still significantly lower than in healthy individuals.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Letter Medicine, General & Internal

SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

Rolando Pajon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Immunology

Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants

Timothy A. Bates et al.

Summary: This study found that individuals who previously recovered from COVID-19 and received vaccination (hybrid immunity) have enhanced immune responses. The effects of post-vaccination breakthrough infections on humoral immune response needs further investigation. However, regardless of whether it occurs before or after vaccination, natural infection substantially boosts the quantity, quality, and breadth of humoral immune response.

SCIENCE IMMUNOLOGY (2022)

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Article Immunology

Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients

Corine H. GeurtsvanKessel et al.

Summary: This study demonstrates that vaccinated individuals retain T cell immunity to the SARS-CoV-2 Omicron variant, despite low levels of neutralizing antibodies. Booster vaccinations can partially restore cross-neutralization of the Omicron variant.

SCIENCE IMMUNOLOGY (2022)

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Letter Infectious Diseases

Antibody titers and protection against a SARS-CoV-2 infection

Chloe Dimeglio et al.

JOURNAL OF INFECTION (2022)

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Article Biochemistry & Molecular Biology

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Shuo Feng et al.

Summary: Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine were identified as correlates of protection against symptomatic infection. Higher levels of immune markers were correlated with a reduced risk of symptomatic infection. The data can be used to extrapolate efficacy estimates to new populations.

NATURE MEDICINE (2021)

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Letter Medicine, General & Internal

Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients

Brian J. Boyarsky et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Medicine, General & Internal

Assessment of 4 Doses of SARS-CoV-2 Messenger RNA-Based Vaccine in Recipients of a Solid Organ Transplant

Nassim Kamar et al.

JAMA NETWORK OPEN (2021)

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Letter Medicine, General & Internal

Safety and Immunogenicity of a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Case Series

William A. Werbel et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Editorial Material Immunology

Antibody Response to a Fourth Dose of a SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Case Series

Jennifer L. Alejo et al.

TRANSPLANTATION (2021)

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Article Multidisciplinary Sciences

Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Donal T. Skelly et al.

Summary: Vaccination with two doses generates more robust immune responses against emerging SARS-CoV-2 variants, particularly B.1.1.7 and B.1.351, compared to natural infection. High magnitude T cell responses are produced after two vaccine doses, mainly targeting conserved epitopes between the original isolate and the variants.

NATURE COMMUNICATIONS (2021)

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A Fourth Dose of COVID-19 Vaccine Does Not Induce Neutralization of the Omicron Variant Among Solid Organ Transplant Recipients With Suboptimal Vaccine Response

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