期刊
TRANSBOUNDARY AND EMERGING DISEASES
卷 69, 期 5, 页码 E3255-E3260出版社
WILEY-HINDAWI
DOI: 10.1111/tbed.14551
关键词
high pathogenicity avian influenza virus; reassortant virus; wild birds
资金
- Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs of the Republic Korea [N-1543418-2020-24-01]
Recent studies indicate that a novel H5N1 virus has been isolated from a captured mandarin duck in South Korea and a quail farm. These viruses are related to the clade 2.3.4.4b H5N1 viruses currently circulating in Europe, providing important insights for future control efforts.
High pathogenicity H5N1 avian influenza viruses pose a threat to both animal and human health worldwide. In late 2020, outbreaks of H5 high pathogenicity avian influenza viruses belonging to clade 2.3.4.4b emerged in Europe, following on from outbreaks in East Asia in earlier years. However, very recent studies show that clade 2.3.4.4b H5N1, rather than 2.3.4.4b H5N8, has become predominant in wild birds and has infected poultry in several countries. In this study, we describe isolation of a novel H5N1 virus from a captured mandarin duck in South Korea, and another H5N1 virus from a quail farm. We performed genetic analysis of these two viruses to identify their origin and to determine their relationship with the clade 2.3.4.4b H5N1 viruses currently circulating in Europe. Based on our results, it is presumed that the novel H5N1 virus isolated in Korea originated from an unknown reassortant between clade 2.3.4.4b H5N8 viruses circulating from 2020 and other Eurasian viruses, with additional reassortment of genes and point mutations that discriminate them from the recently reported H5N1 virus in Europe.
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