期刊
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
卷 116, 期 11, 页码 1022-1031出版社
OXFORD UNIV PRESS
DOI: 10.1093/trstmh/trac035
关键词
anxiety; depression; health-related quality of life; human African trypanosomiasis; mental health
资金
- Small Grant Scheme of the Royal Society of Tropical Medicine and Hygiene
- Sanofi
This study found that former gambiense human African trypanosomiasis (gHAT) patients still experienced neurological sequelae at least 15 years after treatment, leading to higher levels of depression and anxiety, as well as significantly lower quality of life scores in physical, emotional, and mental health domains.
Background The extent to which neuropsychiatric sequelae affects the mental health status and quality of life of former gambiense human African trypanosomiasis (gHAT) patients is not known. Methods We assessed anxiety, depression and health-related quality of life (HRQoL) in 93 patients and their age- and sex-matched controls using the Hospital Anxiety and Depression Scale, Becks Depression Inventory and the 36-item Short Form Health Survey in structured interviews in the Vanga health zone in the Democratic Republic of Congo. Data were analysed using Stata version 14.0. The degree of association between neurologic sequelae and mental distress was evaluated using the Student's t-test and chi(2) or Fisher's exact tests, where appropriate, with a p-value Results We found that neurological sequelae persisted in former patients at least 15 y after treatment. Depression (p<0.001) and anxiety (p=0.001) were significantly higher in former patients with neurologic sequelae. The mean quality-of-life (QoL) scores were significantly lower for patients than in controls in the physical, emotional and mental health domains. Conclusions The presence of neurological sequelae leads to mental distress and a diminished QoL in former gHAT patients. Minimising neurologic sequelae and incorporating psychosocial interventions should be essential management goals for gHAT.
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