☆ 4.7 Review

Cannabis sativa bioactive compounds and their extraction, separation, purification, and identification technologies: An updated review

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

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Article Agriculture, Multidisciplinary

Ultrasound-assisted extraction of oil from hempseed (Cannabis sativa L.): Part 1

Marilena Esposito et al.

Summary: Ultrasound-assisted extraction of intermediate product from mechanical expression of hemp seed oil was investigated to improve expression yield without compromising quality. The optimal ultrasound treatment was found to be 2 minutes at 152 mu m, resulting in a 13.4% oil yield and 73% increase in extraction efficiency compared to the control. Sonication had positive effects on press cake texture and extracted oil antioxidant activity.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2022)

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Article Chemistry, Applied

Chemical profiles of cannabis sativa medicinal oil using different extraction and concentration methods

Cesar N. Pegoraro et al.

Summary: This study compared the variability in chemical profiles of three different varieties of Cannabis sativa extracts using two different extraction and evaporation methods. Results showed that the highest mass of final extract was obtained when extracting inflorescences using the soxhlet method. Heating and the presence of oxygen during solvent evaporation greatly altered the final profiles, emphasizing the importance of careful consideration and standardization in the preparation of medicinal oils.

NATURAL PRODUCT RESEARCH (2021)

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Review Pharmacology & Pharmacy

Hydrophilic Interaction Liquid Chromatography (HILIC): Latest Applications in the Pharmaceutical Researches

Cem Erkmen et al.

Summary: HILIC is an interesting and promising alternative method for the analysis of polar compounds, combining stationary phases used in NPLC with mobile phases used in RPLC. HILIC applications in pharmaceutical research are increasing annually, allowing for simultaneous analysis of multiple compounds using different detectors.

CURRENT PHARMACEUTICAL ANALYSIS (2021)

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Review Chemistry, Analytical

Emerging challenges in the extraction, analysis and bioanalysis of cannabidiol and related compounds

Virginia Brighenti et al.

Summary: CBD is a bioactive compound isolated from cannabis plants and has various pharmaceutical properties, primarily used for treating seizure disorder in children. It is non-psychoactive unlike THC. The market for hemp plant material and related products has expanded rapidly in recent years, with a focus on developing reliable analytical methods for CBD analysis in various samples.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

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Article Biochemical Research Methods

HRMS Detector for the New HILIC CBD Method Development in Hemp Seed Oil

Yu Wang et al.

Summary: The research developed a novel hydrophilic interaction liquid chromatography (HILIC) method for CBD quantitation, specifically for CBD blended hemp seed oil materials, which can overcome matrix buildup in reverse phase columns. The method, developed and validated for the first time, has been successfully applied to quantify CBD content in hemp seed oil samples, demonstrating to be a useful tool for quality control and safety assurance in CBD hemp seed oil raw materials and related products.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

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Review Agricultural Engineering

Cannabis chemistry, post-harvest processing methods and secondary metabolite profiling: A review

Philip Wiredu Addo et al.

Summary: Differences in cannabis plant chemistry among strains are influenced by genetics, growth and environmental conditions, with secondary metabolite profiles further altered post-harvest. Consistent quantity and quality of cannabis extracts are crucial as the therapeutic uses for medical cannabis expand, leading to an increase in extraction and testing laboratories worldwide. However, there is a lack of clarity on standards and numerous non-validated methods being used in the industry.

INDUSTRIAL CROPS AND PRODUCTS (2021)

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Article Chemistry, Applied

GC-MS based metabolomic approach to understand nutraceutical potential of Cannabis seeds from two different environments

Aatif Rashid et al.

Summary: This study conducted an untargeted metabolomic study on cannabis seeds, finding that the Himalayan accession exhibited superior accumulation of nutrients and higher antioxidant and nutraceutical potential compared to the subtropical accession. The exclusive presence of linoleic acid and a-linolenic acid in the seed oil of the Himalayan accession was noted. The environmental impact on the antioxidant and nutraceutical value in seeds was also discussed.

FOOD CHEMISTRY (2021)

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Review Biochemical Research Methods

Extraction of medicinal cannabinoids through supercritical carbon dioxide technologies: A review

Sadia Qamar et al.

Summary: The pharmaceutical importance of cannabinoids in cannabis is growing, making effective extraction and quantification essential for medicinal and forensic purposes. Supercritical fluid extraction (SFE) has gained interest due to its advantages over conventional extraction methods, such as selective extraction, short processing time, low running cost, and minimal environmental impact.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2021)

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Article Plant Sciences

(-)-trans-Δ9-Tetrahydrocannabiphorol Content of Cannabis sativa Inflorescence from Various Chemotypes

Justin Bueno et al.

Summary: The study quantitatively screened the inflorescence content of (-)-trans-Delta(9)-tetrahydrocannabiphorol (Delta(9)-THCP, 1) from six Cannabis sativa chemotypes, revealing a wide variation in content and a potential correlation with the location on the plant.

JOURNAL OF NATURAL PRODUCTS (2021)

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Review Chemistry, Multidisciplinary

Flavonoids in Cannabis sativa: Biosynthesis, Bioactivities, and Biotechnology

Johanna L. Bautista et al.

Summary: While cannabis synthesizes a wide range of phytochemicals, research has primarily focused on two phytocannabinoids, THC and CBD, for their distinctive activities in humans. Flavonoid metabolism and the entourage effect are currently understudied, with cannflavins, unique to cannabis, being a topic of recent research focus. Advances in omics tools are enabling further exploration of flavonoid metabolism and manipulation of flavonoid production for potential health benefits and drug development.

ACS OMEGA (2021)

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Article Biochemistry & Molecular Biology

A Rapid Nano-Liquid Chromatographic Method for the Analysis of Cannabinoids in Cannabis sativa L. Extracts

Lucie Zampachova et al.

Summary: In this study, a rapid nano liquid chromatographic method was proposed for determining the main cannabinoids in different varieties of cannabis inflorescences. The research demonstrated that three different extraction methods showed varying results, and the nano-LC method combined with UV detection could be used for the quantification of target components in cannabis extracts.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Development of a Novel Microwave Distillation Technique for the Isolation of Cannabis sativa L. Essential Oil and Gas Chromatography Analyses for the Comprehensive Characterization of Terpenes and Terpenoids, Including Their Enantio-Distribution

Giuseppe Micalizzi et al.

Summary: An optimized microwave distillation method was developed for the extraction and isolation of cannabis essential oil, yielding a product rich in terpenes and terpenoid compounds. Characterization and absolute quantification of the distillate from different hemp cultivars were achieved using gas chromatography equipped with mass spectrometer and flame ionization detectors. Additionally, an enantio-GC-MS method was established to evaluate the enantiomeric distribution of chiral compounds.

MOLECULES (2021)

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Review Biochemistry & Molecular Biology

Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis

Mohamed M. Radwan et al.

Summary: Cannabis sativa, one of the oldest medicinal plants in the world, contains a complex mixture of secondary metabolites, with cannabinoids and non-cannabinoid constituents being the main components. This review focuses on the chemistry of cannabinoids and major non-cannabinoid constituents, discussing their chemical structures, methods of isolation, and identification.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

New Insights on Hemp Oil Enriched in Cannabidiol: Decarboxylation, Antioxidant Properties and In Vitro Anticancer Effect

Anca Roxana Petrovici et al.

Summary: The study found that CBD-enriched hemp oil has antioxidant properties in oxidative conditions and promotes the proliferation of normal fibroblasts, while inducing apoptosis and ROS production in cancer cells.

ANTIOXIDANTS (2021)

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Article Plant Sciences

Different Cannabis sativa Extraction Methods Result in Different Biological Activities against a Colon Cancer Cell Line and Healthy Colon Cells

Jan Rozanc et al.

Summary: Different extraction methods of cannabis were tested for their effects on cannabinoid content, antioxidant properties, and bioactivity on colon cancer and healthy colon cells. The results showed that properly prepared cannabis extracts can reduce cancer cell viability while protecting healthy cells. However, the post-processing of extracts poses a limitation in predicting therapeutic response based on the original composition.

PLANTS-BASEL (2021)

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Article Agricultural Engineering

Chemical composition and antioxidant potential of Cannabis sativa L. roots

Christoph Kornpointner et al.

Summary: This study investigated the secondary metabolite composition and antioxidant activities of hemp roots from three chemovars, revealing the presence of five triterpenes, ten phytosterols, and five aliphatic compounds in the root extracts. Some compounds, such as glutinol, beta-amyrone, and stigmastanol, were identified for the first time in cannabis roots. The predominant triterpenoids friedelin and epifriedelinol were quantified, showing dependence on different factors like chemovar, harvest times, drying conditions, and extraction methods.

INDUSTRIAL CROPS AND PRODUCTS (2021)

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Article Chemistry, Analytical

Discrimination of CBD-, THC- and CBC-type acid cannabinoids through diagnostic ions by UHPLC-HR-MS/MS in negative ion mode

Simona Piccolella et al.

Summary: The interest in industrial hemp-based products in the food and nutraceutical sector has led to a demand for improved analytical methods for rapidly discriminating acid phytocannabinoid isomers. A study using high-resolution MS/MS investigated the reactivity of common pre-cannabinoids, providing new insights for differentiation of pre-cannabinoid homologues.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

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Article Biochemistry & Molecular Biology

A Comparative Study of Pyrolysis Liquids by Slow Pyrolysis of Industrial Hemp Leaves, Hurds and Roots

Ayobami Salami et al.

Summary: This study assessed the chemical composition of pyrolysis liquids obtained from different parts of industrial hemp through slow pyrolysis, revealing the presence of various compounds with economic potential. Analysis techniques such as NMR, GC-MS, and APPI FT-ICR MS were used to identify the most abundant compounds and compound groups in the aqueous and oily fractions.

MOLECULES (2021)

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Article Multidisciplinary Sciences

Increasing medicinal and phytochemical compounds of coneflower (Echinacea purpurea L.) as affected by NO3-/NH4+ ratio and perlite particle size in hydroponics

Fatemeh Ahmadi et al.

Summary: The study aimed to improve the caffeic acid derivatives and alkylamides percentages of Echinacea purpurea root extract in hydroponic culture media by adjusting perlite particle size and NO3-/NH4+ ratios. Results showed that a perlite to peat moss ratio of 50:50 with very fine perlite led to the highest levels of these compounds. This indicates that optimizing hydroponic culture media and nutrient solution has significant effects on E. purpurea chemical compounds.

SCIENTIFIC REPORTS (2021)

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Review Biochemistry & Molecular Biology

Extraction of Phenolic Compounds and Terpenes from Cannabis sativa L. By-Products: From Conventional to Intensified Processes

Emilie Isidore et al.

Summary: This paper highlights the main phenolic compounds and terpenes in cannabis by-products, along with their biological activities and extraction techniques. The discussion includes the impact of operating conditions on the yield and composition of these compounds, emphasizing the importance of innovative extraction techniques for sustainable industrial valorization of cannabis.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Antioxidant Activity of Hemp (Cannabis sativa L.) Seed Oil in Drosophila melanogaster Larvae under Non-Stress and H2O2-Induced Oxidative Stress Conditions

Jelena Vitorovic et al.

Summary: Hemp seed oil, rich in nutrients, shows potential benefits for preventing oxidative stress and treating conditions caused by oxidative stress. Studies demonstrate that hemp seed oil can improve the oxidative state of D. melanogaster within a certain concentration range without inducing negative effects, exhibiting antioxidant properties.

ANTIOXIDANTS (2021)

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Article Chemistry, Multidisciplinary

Medicinal Cannabis - The Green Fairy Phenomenon

Onyekachi Raymond et al.

Summary: Restrictions on accessing prescribed cannabinoids in New Zealand have led to a black market of homemade cannabis-based products known as 'Green Fairies'. These products vary widely in cannabinoid concentrations and often lack consistency in the claimed CBD content. Analysis of different cannabis cultivars used in these products also showed little variation in THC and CBD levels, highlighting potential concerns over product quality and efficacy.

AUSTRALIAN JOURNAL OF CHEMISTRY (2021)

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Review Biochemical Research Methods

Gas chromatographic analysis of naturally occurring cannabinoids: A review of literature published during the past decade

Lutfun Nahar et al.

PHYTOCHEMICAL ANALYSIS (2020)

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Article Chemistry, Analytical

LEGO MINDSTORMS Fraction Collector: A Low-Cost Tool for a Preparative High-Performance Liquid Chromatography System

Marco Caputo et al.

ANALYTICAL CHEMISTRY (2020)

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Article Food Science & Technology

Effects of supercritical and liquid carbon dioxide extraction on hemp (Cannabis sativa L.) seed oil

Alessandra Aiello et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Microwave-assisted extraction of cannabinoids and antioxidants from Cannabis sativa aerial parts and process modeling

Zorica Drinic et al.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2020)

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Article Plant Sciences

Isolation of a High-Affinity Cannabinoid for the Human CB1 Receptor from a Medicinal Cannabis sativa Variety: Δ9-Tetrahydrocannabutol, the Butyl Homologue of Δ9-Tetrahydrocannabinol

Pasquale Linciano et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Review Biochemical Research Methods

A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010-2019)

Lutfun Nahar et al.

PHYTOCHEMICAL ANALYSIS (2020)

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Article Biochemical Research Methods

Development of extraction technique and GC/FID method for the analysis of cannabinoids in Cannabis sativa L. spp. santicha (hemp)

Juste Baranauskaite et al.

PHYTOCHEMICAL ANALYSIS (2020)

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Article Biochemistry & Molecular Biology

Cannabis sativa L. Inflorescences from Monoecious Cultivars Grown in Central Italy: An Untargeted Chemical Characterization from Early Flowering to Ripening

Cinzia Ingallina et al.

MOLECULES (2020)

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Article Chemistry, Applied

Development, validation and application of a LC-MS/MS method for quantification of 15 cannabinoids in food

Nicolas Christinat et al.

FOOD CHEMISTRY (2020)

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Review Oncology

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Andrea M. Tomko et al.

CANCERS (2020)

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Article Chemistry, Analytical

Innovative methods for the preparation of medical Cannabis oils with a high content of both cannabinoids and terpenes

Marco Ternelli et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)

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Article Biochemical Research Methods

Quantitative determination and validation of 17 cannabinoids in cannabis and hemp using liquid chromatography-tandem mass spectrometry

Garnet McRae et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Physical

Extraction of cannabinoids from hemp (Cannabis sativa L.) using high pressure solvents: An overview of different processing options

Teresa Moreno et al.

JOURNAL OF SUPERCRITICAL FLUIDS (2020)

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Article Biochemical Research Methods

Effect-directed analysis of bioactive compounds in Cannabis sativa L. by high-performance thin-layer chromatography

Giulia Corni et al.

JOURNAL OF CHROMATOGRAPHY A (2020)

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Article Plant Sciences

Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Cannabis sativa L., Is a Selective Thermo-TRP Modulator

Giuseppina Chianese et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Review Nutrition & Dietetics

Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies

Gopalsamy Rajiv Gandhi et al.

NUTRIENTS (2020)

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Article Engineering, Chemical

Pressurized Liquid Extraction of Cannabinoids from Hemp Processing Residues: Evaluation of the Influencing Variables

Sebastian Serna-Loaiza et al.

PROCESSES (2020)

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Article Food Science & Technology

Chemical Composition and Antioxidant Activity of Thyme, Hemp and Coriander Extracts: A Comparison Study of Maceration, Soxhlet, UAE and RSLDE Techniques

Sara Palmieri et al.

FOODS (2020)

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Article Multidisciplinary Sciences

Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol

Pasquale Linciano et al.

SCIENTIFIC REPORTS (2020)

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Article Biology

Toward the identification of a phytocannabinoid-like compound in the flowers of a South African medicinal plant (Leonotis leonurus)

E. Hunter et al.

BMC RESEARCH NOTES (2020)

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Article Chemistry, Multidisciplinary

Metabolic Changes in the Trichomes of Cannabis sativa var. bedrobinol Analyzed by 1H-NMR-Based Metabolomics

Nizar Happyana et al.

INDONESIAN JOURNAL OF CHEMISTRY (2020)

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Article Chemistry, Physical

Supercritical fluid technologies applied to the extraction of compounds of industrial interest from Cannabis sativa L. and to their pharmaceutical formulations: A review

Lucia Baldino et al.

JOURNAL OF SUPERCRITICAL FLUIDS (2020)

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Article Chemistry, Analytical

Study of the Kinetics of Extraction Process for The Production of Hemp Inflorescences Extracts by Means of Conventional Maceration (CM) and Rapid Solid-Liquid Dynamic Extraction (RSLDE)

Monica Gallo et al.

SEPARATIONS (2020)

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Article Biochemistry & Molecular Biology

Characterization of bioactive compounds in defatted hempseed (Cannabis sativa L.) by UHPLC-HRMS/MS and anti-inflammatory activity in primary human monocytes

Julio Rea Martinez et al.

FOOD & FUNCTION (2020)

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Article Agricultural Engineering

Can agronomic practices and cold-pressing extraction parameters affect phenols and polyphenols content in hempseed oils?

Salvatore Faugno et al.

INDUSTRIAL CROPS AND PRODUCTS (2019)

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Article Biochemical Research Methods

Rapid isolation of acidic cannabinoids from Cannabis sativa L. using pH-zone-refining centrifugal partition chromatography

Johannes R. Popp et al.

JOURNAL OF CHROMATOGRAPHY A (2019)

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Article Chemistry, Physical

Extraction, isolation and purification of tetrahydrocannabinol from the Cannabis sativa L. plant using supercritical fluid extraction and solid phase extraction

Ada C. Gallo-Molina et al.

JOURNAL OF SUPERCRITICAL FLUIDS (2019)

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Article Biochemical Research Methods

Development of a new method for the analysis of cannabinoids in honey by means of high-performance liquid chromatography coupled with electrospray ionisation-tandem mass spectrometry detection

Virginia Brighenti et al.

JOURNAL OF CHROMATOGRAPHY A (2019)

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Article Food Science & Technology

Microwave-assisted extraction of hempseed oil: studying and comparing of fatty acid composition, antioxidant activity, physiochemical and thermal properties with Soxhlet extraction

Amir Rezvankhah et al.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2019)

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Review Biochemistry & Molecular Biology

Terpenes in Cannabis sativa - From plant genome to humans

Judith K. Booth et al.

PLANT SCIENCE (2019)

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Review Food Science & Technology

Rapid Solid-Liquid Dynamic Extraction (RSLDE): A Powerful and Greener Alternative to the Latest Solid-Liquid Extraction Techniques

Daniele Naviglio et al.

FOODS (2019)

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Article Biochemical Research Methods

Thin layer chromatography in the analysis of cannabis and its components and synthetic cannabinoids

Joseph Sherma et al.

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES (2019)

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Article Biochemical Research Methods

Analysis of tetrahydrocannabinol derivative from cannabis-infused chocolate by QuEChERS-thin layer chromatography-desorption electrospray ionization mass spectrometry

Maryam Yousefi-Taemeh et al.

JOURNAL OF MASS SPECTROMETRY (2019)

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Article Chemistry, Physical

Green extraction of cannabidiol from industrial hemp (Cannabis sativa L.) using deep eutectic solvents coupled with further enrichment and recovery by macroporous resin

Changyong Cai et al.

JOURNAL OF MOLECULAR LIQUIDS (2019)

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Article Biochemistry & Molecular Biology

Biosynthesis of cannflavins A and B from Cannabis sativa L

Kevin A. Rea et al.

PHYTOCHEMISTRY (2019)

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Article Chemistry, Analytical

Analysis of impurities of cannabidiol from hemp. Isolation, characterization and synthesis of cannabidibutol, the novel cannabidiol butyl analog

Cinzia Citti et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2019)

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Article Nutrition & Dietetics

PipeNig®-FL, a Fluid Extract of Black Pepper (Piper Nigrum L.) with a High Standardized Content of Trans-β-Caryophyllene, Reduces Lipid Accumulation in 3T3-L1 Preadipocytes and Improves Glucose Uptake in C2C12 Myotubes

Federica Geddo et al.

NUTRIENTS (2019)

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Article Biochemistry & Molecular Biology

Chemical Characterization of Leaves, Male and Female Flowers from Spontaneous Cannabis (Cannabis sativa L.) Growing in Hungary

David U. Nagy et al.

CHEMISTRY & BIODIVERSITY (2019)

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Article Chemistry, Physical

Hemp (Cannabis sativa L.) seed oil extraction with pressurized n-propane and supercritical carbon dioxide

Daniel Ribeiro Grijo et al.

JOURNAL OF SUPERCRITICAL FLUIDS (2019)

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Article Multidisciplinary Sciences

A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol:Δ9-Tetrahydrocannabiphorol

Cinzia Citti et al.

SCIENTIFIC REPORTS (2019)

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Review Biochemistry & Molecular Biology

Cannabis Phenolics and their Bioactivities

Federica Pollastro et al.

CURRENT MEDICINAL CHEMISTRY (2018)

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Article Chemistry, Applied

Nutraceutical potential of hemp (Cannabis sativa L.) seeds and sprouts

Stefania Frassinetti et al.

FOOD CHEMISTRY (2018)

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Article Agricultural Engineering

Variation in the compositions of cannabinoid and terpenoids in Cannabis sativa derived from inflorescence position along the stem and extraction methods

Dvory Namdar et al.

INDUSTRIAL CROPS AND PRODUCTS (2018)

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Article Agricultural Engineering

Utilisation of supercritical fluids for the effective extraction of waxes and Cannabidiol (CBD) from hemp wastes

Thomas M. Attard et al.

INDUSTRIAL CROPS AND PRODUCTS (2018)

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Article Biochemical Research Methods

Implementation of a generic SFC-MS method for the quality control of potentially counterfeited medicinal cannabis with synthetic cannabinoids

Hugues Jambo et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)

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Article Green & Sustainable Science & Technology

Menthol-based hydrophobic deep eutectic solvents: Towards greener and efficient extraction of phytocannabinoids

Tomas Krizek et al.

JOURNAL OF CLEANER PRODUCTION (2018)

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Article Food Science & Technology

Ultrasound-Assisted Extraction of Cannabinoids from Cannabis Sativa L. Optimized by Response Surface Methodology

Charu Agarwal et al.

JOURNAL OF FOOD SCIENCE (2018)

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Article Chemistry, Analytical

Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)

Cinzia Citti et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2018)

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Article Plant Sciences

Detection and Quantification of Cannabinoids in Extracts of Cannabis sativa Roots Using LC-MS/MS

Waseem Gul et al.

PLANTA MEDICA (2018)

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Article Plant Sciences

Identification of Putative Precursor Genes for the Biosynthesis of Cannabinoid-Like Compound in Radula marginata

Tajammul Hussain et al.

FRONTIERS IN PLANT SCIENCE (2018)

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Article Chemistry, Applied

Effect of Solvent, Preheating Temperature, and Time on the Ultrasonic Extraction of Phenolic Compounds from Cold-Pressed Hempseed Cake

Jingbang Liang et al.

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (2018)

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Article Biochemistry & Molecular Biology

New Methods for the Comprehensive Analysis of Bioactive Compounds in Cannabis sativa L. (hemp)

Federica Pellati et al.

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Review Biotechnology & Applied Microbiology

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

Federica Pellati et al.

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Agnieszka Janeczek et al.

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Stilbenoids and cannabinoids from the leaves of Cannabis sativa f. sativa with potential reverse cholesterol transport activity

Tiantian Guo et al.

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Article Medicine, Legal

Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection

Mei Wang et al.

JOURNAL OF FORENSIC SCIENCES (2017)

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Article Chemistry, Medicinal

Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum

Federica Pollastro et al.

FITOTERAPIA (2017)

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Article Chemistry, Analytical

Development of a new extraction technique and HPLC method for the analysis of non-psychoactive cannabinoids in fibre-type Cannabis sativa L. (hemp)

Virginia Brighenti et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2017)

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Article Chemistry, Physical

Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.

Laura J. Rovetto et al.

JOURNAL OF SUPERCRITICAL FLUIDS (2017)

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Article Multidisciplinary Sciences

Terpene synthases from Cannabis sativa

Judith K. Booth et al.

PLOS ONE (2017)

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Review Pharmacology & Pharmacy

Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?

E. Joseph Brand et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Article Chemistry, Medicinal

A Reliable Method for the Separation and Detection of Synthetic Cannabinoids by Supercritical Fluid Chromatography with Mass Spectrometry, and Its Application to Plant Products

Toshimasa Toyo'oka et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2015)

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