期刊
TOXICOLOGY LETTERS
卷 356, 期 -, 页码 143-150出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2021.11.012
关键词
Arsenic; Apoptosis; Neurone; Fas-FasL-FADD signal pathway; ZB4
类别
资金
- National Natural Science Foundation of China [81903265, 81573097]
This study found that arsenic induces neurotoxicity by activating the Fas-FasL-FADD signaling pathway and inducing neuronal apoptosis.
The molecular mechanisms underlying arsenic-induced neurotoxicity have not been completely elucidated. Our study aimed to determine the role of the Fas-FasL-FADD signaling pathway in arsenic-mediated neuronal apoptosis. Pathological and molecular biological tests were performed on the cerebral cortex of arsenic-exposed rats and SH-SY5Y neuroblastoma cells. Arsenic induced apoptosis in the cortical neurons, which corresponded to abnormal ultrastructural changes. Mechanistically, arsenic activated the Fas-FasL-FADD signaling pathway and the downstream caspases both in vivo and in vitro. ZB4 treatment reversed the apoptotic effects of arsenic on the SHSY5Y cells. Taken together, arsenic induces neurotoxicity by activating the Fas-FasL-FADD signaling pathway. (c) 2021 Harbin Medical University. Published by Elsevier B.V.
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