4.2 Review

Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review

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Summary: The study found that TDM can promote the odontogenic differentiation of human dental pulp stem cells, decrease the expression of GSK3 beta, and activate the Wnt/beta-catenin signaling pathway, thereby promoting the generation of new dentin.

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Summary: In this clinical study, it was found that using TDMH, Biodentine, and MTA for direct pulp capping showed good dentin regeneration ability with no inflammatory response. However, the dentin formed in the TDMH group was significantly thicker with well-arranged odontoblasts, indicating a positive trend towards dentin regeneration.

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Peptide decorated demineralized dentin matrix with enhanced bioactivity, osteogenic differentiation via carboxymethyl chitosan

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Summary: The study aimed to evaluate radiographic changes and histologic healing following alveolar ridge preservation using autogenous whole tooth (AWTG) and autogenous demineralized dentin graft (ADDG). Both AWTG and ADDG were found to be similarly effective in ARP, with ADDG demonstrating better graft remodeling, integration, and osteoinductive properties histologically.

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Dentin-Derived-Barrier Membrane in Guided Bone Regeneration: A Case Report

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Summary: This study reported a successful outcome in guided bone regeneration and dental implantation using a dentin-derived-barrier membrane made from autogenous demineralized dentin matrix. The novel human-derived collagen membrane overcame mechanical instability issues and demonstrated good osteo-inductive properties and mechanical stability in comparison with traditional methods. Further research should focus on evaluating bone forming capacity in large numbers of patients.

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Summary: A bio-ink based on demineralized dentin matrix (DDM) particles with enhanced 3D printability was developed for engineering dental tissues. The higher the DDM particle concentration, the better the printability and cell compatibility of the bio-ink, leading to improved printing resolution and stacking ability. The study demonstrated the successful fabrication of cellular constructs with 3D patient-specific shapes and clinically relevant sizes through co-printing with polycaprolactone and DDM particle-laden bio-ink.

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Liposomal Delivery of Demineralized Dentin Matrix for Dental Tissue Regeneration

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