期刊
JOURNAL OF APPLIED TOXICOLOGY
卷 37, 期 6, 页码 692-698出版社
WILEY
DOI: 10.1002/jat.3417
关键词
Bovine; Cell proliferation; Glyphosate; Granulosa cell; Theca cell; Steroidogenesis
类别
资金
- Oklahoma State University Agricultural Experiment Station
Glyphosate (GLY) is a common herbicide used worldwide but its effect on ovarian function in mammals is unknown. The aim of this study was to determine the potential endocrine disruptor effects of GLY on ovarian function evaluating cell proliferation, steroidogenesis and gene expression using bovine granulosa cells (GC) and theca cells as in vitro models. GC proliferation was impaired (P<0.05) after exposure to GLY at 0.5, 1.7 and 5gml(-1). GC progesterone production was not affected (P0.05) at all doses tested while estradiol production was inhibited (P<0.05) by GLY at 5gml(-1). At the same concentration GLY showed no effect (P0.05) on theca cell proliferation and steroidogenesis. At higher concentrations (0.01 and 0.3mgml(-1)), GLY had no significant effect (P0.05) on GC proliferation and steroidogenesis. These studies, for the first time, suggest that GLY may affect the reproductive system in cattle via direct action on ovarian function; however, further studies will be required to understand better the mechanism of action and to determine the in vivo reproductive effects of GLY. Copyright (c) 2016 John Wiley & Sons, Ltd.
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