Asymmetric Henry reaction using a double fluorous-tagged Co-salen complex

A highly stereoselective asymmetric Henry reaction using a double fluorous-tagged Co-salen complex was conducted. The introduction of two fluorous tags into the Co-salen complex was found to be more effective in terms of improving stereoselectivity than the introduction of a strong electron-withdrawing nitro group into the same position of the salen ligand. The observed stereoselectivity was significantly higher than that when using a Jacobsen-type Co-salen complex bearing the same asymmetric source. (c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

A highly stereoselective asymmetric Henry reaction was achieved using a double fluorous-tagged Co-salen complex, which showed improved stereoselectivity compared to introducing a nitro group in the same position of the salen ligand. The observed stereoselectivity was significantly higher than that of a Jacobsen-type Co-salen complex with the same asymmetric source.