Visible-light-induced radical cyclization of N-allylbenzamide with [Bis (difluoroacetoxy)iodo]benzene to difluoromethylated dihydroisoquinolinones

A visible light-induced radical difluoromethylation of N-allylbenzamide by [bis(difluoroacetoxy)iodo] benzene to prepare difluoromethylated dihydroisoquinolinones was developed for the first time. To facilitate the oxidative aromatization step, PhI(OAc)(2) was employed as oxidant. The inexpensive and readily accessible reagents and the mild reaction conditions render this method an efficient and practical strategy for the synthesis of difluoromethylated dihydroisoquinolinones. (C) 2022 Elsevier Ltd. All rights reserved.

Automated summary

A visible light-induced radical difluoromethylation reaction was developed for the synthesis of difluoromethylated dihydroisoquinolinones. This method employs inexpensive and readily accessible reagents, and the reaction conditions are mild, making it an efficient and practical synthetic strategy.