Organocatalytic one-pot asymmetric synthesis of 6-trifluoromethyl-substituted 7,8-dihydrochromen-6-ol

A squaramide organocatalyst efficiently promoted the asymmetric Friedel-Crafts alkylation of oc,6-unsat-urated trifluoromethyl ketones with aromatic alcohols in a one-pot procedure, affording corresponding 6trifluoromethyl-substituted 7,8-dihydrochromen-6-ol derivatives (up to 94% yield, 74% ee). (c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

A novel squaramide organocatalyst efficiently promoted the asymmetric Friedel-Crafts alkylation of oc,6-unsaturated trifluoromethyl ketones with aromatic alcohols, affording the corresponding 6-trifluoromethyl-substituted 7,8-dihydrochromen-6-ol derivatives in high yields and enantioselectivity.