Assembly of the Hydroxycinnoline Core via Hydrazide-Assisted Rh(III)-Catalyzed C-H Functionalization and Annulation

The structural modification of phthalazinones and indazolones has emerged as a pivotal topic in catalytic C-H functionalization events. Herein we report the hydrazide-assisted rhodium(III)-catalyzed cross-coupling reactions of N-arylphthalazinones and N-arylindazolones with vinylene carbonate. This method provides direct access to tetracyclic hydroxycinnolines. Complete site-selectivity and functional group compatibility were observed.

Automated summary

The hydrazide-assisted rhodium(III)-catalyzed cross-coupling reactions of N-arylphthalazinones and N-arylindazolones with vinylene carbonate were reported, providing direct access to tetracyclic hydroxycinnolines. The reactions exhibited complete site-selectivity and functional group compatibility.