Concise Synthesis of Procyanidin B2 3,3-Digallate Using Yb(OTf)3-Mediated Self-Condensation

Lewis acid mediated self-condensation of epicatechin gallate derivative was examined. We found that Yb(OTf)(3) afforded good yield of the dimeric epicatechin gallate derivative. The condensed product was applied to the synthesis of procyanidin B2 3,3 ''-digallate.

Automated summary

This study investigated the Lewis acid mediated self-condensation of epicatechin gallate derivative. It was found that Yb(OTf)3 provided a good yield of dimeric epicatechin gallate derivative, which was then used for the synthesis of procyanidin B2 3,3''-digallate.