2-Iodoxybenzoic Acid-Dimethyl Sulfoxide (IBX-DMSO)-Promoted Oxidative Aromatization of Spiro[2.5]octa-4,7-dien-6-one

A 2-iodoxybenzoic acid (IBX)-dimethyl sulfoxide (IBX-DM-50)-promoted oxidative aromatization of spiro[2.5]octa-4,7-dien-6-ones has been developed. A series of substrates with various substitutions were transformed into oxidative aromatization products in good to excellent yields. This oxidative aromatization features environmentally friendly reagents, high efficiency, a broad substrate scope, broad functional-group tolerance, and mild reaction conditions.

Automated summary

A new method for the oxidative aromatization of spiro[2.5]octa-4,7-dien-6-ones using 2-iodoxybenzoic acid (IBX)-dimethyl sulfoxide (IBX-DM-50) as the promoter has been developed. This method allows for the transformation of various substrates with different substituents into aromatization products with high efficiency. It features environmentally friendly reagents, broad substrate scope, broad functional-group tolerance, and mild reaction conditions.