Synthesis of 1,5-Disubstituted Tetrazoles from Nitrones by Using Bis(p-nitrophenyl) Phosphorazidate in the Presence of 4-(Dime-thylamino)pyridine

A novel method has been developed for the synthesis of 1,5-disubstituted tetrazoles from nitrones by using bis(p-nitrophenyl) phosphorazidate in the presence of 4-(dimethylamino)pyridine. By this approach, various nitrones were converted into the corresponding tetrazoles. This method permits the preparation of 1,5-disubstituted tetrazoles without the need for toxic or explosive reagents.

Automated summary

A novel method has been developed for the synthesis of 1,5-disubstituted tetrazoles from nitrones, allowing the preparation of tetrazoles without the need for toxic or explosive reagents.