Copper-Mediated Direct Aromatic ortho-C-H Cyanation by AIBN

We have developed a copper-mediated chelation-assisted direct aromatic ortho-C-H cyanation that uses AIBN as a safe cyanation reagent. The substrate scope included indoles, pyrroles, a carbazole, and a thiophene.

Automated summary

In this study, a copper-mediated chelation-assisted direct aromatic ortho-C-H cyanation using AIBN as a safe cyanation reagent was developed. The reaction successfully achieved cyanation of substrates including indoles, pyrroles, a carbazole, and a thiophene.