期刊
SYNLETT
卷 33, 期 11, 页码 1087-1091出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1828-0352
关键词
lusianthridin; dihydrophenanthrene; Suzuki-Miyaura reaction; intramolecular nucleophilic substitution; large-scale preparation of stilbenoids
资金
- National Natural Science Foundation of China [22001172, 22071155, 21871184]
- Shanghai Municipal Education Commission [2019-01-07-00-10-E00072]
- Shanghai Sailing Program [20YF1449300]
- Chenguang Program [20CG52]
- Program of Shanghai Academic/Technology Research Leader [20XD1403600]
- Science and Technology Commission of Shanghai Municipality [20400750300]
- Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine [ZYYCXTD-202004]
An efficient synthesis of the stilbenoid lusianthridin is described, wherein a Suzuki-Miyaura coupling and an intramolecular nucleophilic substitution are employed as key reactions to construct the 9,10-dihydrophenanthrene core. The synthesis is accomplished in seven steps with a 13.2% overall yield, and each step can be conducted on a >20 gram scale. This route has provided 20 grams of lusianthridin for further biological activity studies.
The efficient preparation of the stilbenoid lusianthridin is described. This synthesis relies on a Suzuki-Miyaura coupling and an intramolecular nucleophilic substitution as key reactions to construct the 9,10-dihydrophenanthrene core. The synthesis is completed in seven steps with a 13.2% overall yield, and each step can be conducted on a >20 gram scale. The route has provided 20 grams of lusianthridin for further biological activity studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
