Amine Oxidation by Electrochemically Generated Peroxodicarbonate

The N-oxidation of tertiary amines was achieved by using electrochemically generated peroxodicarbonate solutions as sustainable oxidizers. The presence of EDTA and 2,2,2-trifluoroacetophenone as a mediator was found to be crucial for converting water-insoluble substrates. Various tertiary amines were converted into their corresponding N-oxides in yields of up to 98%. The scope includes economically important surfactants and potential platform oxidizers.

Automated summary

The N-oxidation of tertiary amines can be achieved using electrochemically generated peroxodicarbonate solutions. The presence of EDTA and 2,2,2-trifluoroacetophenone as mediators is crucial for converting water-insoluble substrates.