Cytokinetic-driven myeloprotection after cytotoxic chemotherapy: from an old idea to a new clinical approach

Chemotherapy is the backbone of the treatment of several solid tumours and lymphomas. Myelotoxicity is often a dose-limiting toxicity and myeloprotection has always been investigated. In fact, over the years, several approaches have been studied in order to reduce the incidence of haematological toxicities and allow patients to receive effective, full-dose, chemotherapy. After the use of stimulating factors, such as granulocyte colony-stimulating factors and erythropoiesis-stimulating agents, in the very last years, a new approach has emerged. Trilaciclib, a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor, has been studied and it has been demonstrated in several clinical trials to reduce the incidence of myelotoxicity in small-cell lung cancer patients treated with chemotherapy or chemo-immunotherapy. Its potential role has not been fully studied yet, but it represents a highly effective tool to reduce myelotoxicity, widen the applicability of full-dose chemotherapy, even in frailer patients, and finally to increase the efficacy of chemotherapy in those tumours where relative dose intensity is a standard to achieve to get the best clinical results.

Automated summary

Chemotherapy is a commonly used treatment for solid tumors and lymphomas, but its effectiveness is limited by myelotoxicity. In recent years, a new approach involving the use of Trilaciclib, a CDK4/6 inhibitor, has shown promise in reducing myelotoxicity in small-cell lung cancer patients receiving chemotherapy or chemo-immunotherapy. Trilaciclib has the potential to improve the effectiveness of chemotherapy by reducing myelotoxicity and expanding its applicability to frailer patients.