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Confounding factors in the assessment of oral mucositis in head and neck cancer

期刊

SUPPORTIVE CARE IN CANCER
卷 30, 期 10, 页码 8455-8463

出版社

SPRINGER
DOI: 10.1007/s00520-022-07128-w

关键词

Mucositis; Head and neck; Supportive care; Simultaneous care; Radiation toxicities

资金

  1. Universita degli Studi di Brescia within the CRUI-CARE Agreement

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This paper reviews the confounding factors of oral mucositis related to head and neck cancer patients.
Treatment of locally advanced head and neck carcinoma not amenable for surgical resection or resected with high-risk features is usually based on (chemo-)radiation treatment. Oral mucositis represents one of the main side effects of (chemo-)radiation, with an important impact on quality of life and causing approximately 20% of early interruption of treatment, leading to a suboptimal dose administered. Treatment and prevention of oral mucositis have a central role in the therapeutic pathways of head and neck cancer patients but remains quite challenging. Although extensive research is conducted to identify interventions for the management of mucositis, very few interventions had sufficient evidence to generate an international expert consensus. This may be partially explained by confounding factors that could influence the development and assessment of oral mucositis. Little is known about the confounding factors of oral mucositis, which, if not well balanced in an experimental study, could lead to non-solid results. The current paper aims to review the main oral mucositis confounding factors related to head and neck cancer patients.

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