Cartwheels create symmetry and asymmetry

Article Biochemistry & Molecular Biology

Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

Anastassia L. Kantsadi et al.

Summary: Centrioles are eukaryotic organelles that play important roles in cellular processes like cilia and flagella formation, microtubule network organization, and mitotic spindle assembly. This research reveals that the asymmetric interaction mediated by the coiled-coil domain of SAS-6 is crucial for the assembly and polarity of the centriolar central scaffold, the cartwheel. Disrupting this asymmetric interaction impairs the stacking of SAS-6 rings. These findings provide new insights into the assembly of centrioles and cell division.

STRUCTURE (2022)

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Article Biochemistry & Molecular Biology

Overview of the centriole architecture

Maeva LeGuennec et al.

Summary: The centriole, a complex molecular assembly in eukaryotic cells, remains unsolved in terms of its atomic structure. However, advancements in electron microscopy, cryo-tomography, and super-resolution studies have allowed for a better understanding of its global architecture. This review highlights the current knowledge on the organization of centrioles, including substructural elements and differences between species, with a focus on the limitations hindering a complete atomic view of their architecture.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology