Generation of a human iPSC line, INMi005-A, from a patient with non-syndromic USH2A-associated retinitis pigmentosa

We report here the generation of the human iPSC line INMi005-A from a patient with non-syndromic autosomal recessive retinitis pigmentosa caused by compound heterozygous mutations in the USH2A gene. The reprogramming of primary human dermal fibroblasts was performed using the non-integrative Sendai virus method and the OSKM transcription factor cocktail. The generated INMi005-A iPSC line is pluripotent and genetically stable, and will represent a valuable tool for understanding the pathophysiology associated with USH2A mutations.

Automated summary

We report the generation of a human iPSC line from a patient with autosomal recessive retinitis pigmentosa using the non-integrative Sendai virus method. The generated iPSC line is pluripotent and genetically stable, and will serve as a valuable tool for studying the pathophysiology associated with the disease.