期刊
STEM CELL RESEARCH
卷 61, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scr.2022.102743
关键词
-
资金
- Japan Society for the Promotion of Science (JSPS) [12 J09944]
- Kanazawa Medical University [11181, 26699]
This study reprogrammed peripheral blood mononuclear cells from a patient with hereditary hemorrhagic telangiectasia type 2, using episomal vectors, in order to establish an in vitro model for the disease.
Telangiectasia, hereditary hemorrhagic, type 2 (HHT2) is a rare autosomal dominant disease caused by a mutated ACVRL1 gene (Letteboer et al., 2005). The peripheral blood mononuclear cells (PBMCs) from a patient carrying a heterozygous 2 bp duplication in intron 6 of the ACVRL1 gene, NG_009549.1(NM_000020.2): c.772 + 3_772 + 4dup, were reprogrammed using episomal vectors. The inserted mutation in ACVRL1 will causes the abnormal splicing, which will be associated with HHT2. The cell line will enable proper in vitro disease modelling of HHT2(Roman and Hinck, 2017).
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