Generation of iPS cell line (ICGi040-A) from skin fibroblasts of a patient with ring small supernumerary marker chromosome 4

Human induced pluripotent stem cell (iPSC) line, ICGi040-A, was obtained from skin fibroblasts derived from a male patient with mosaic ring small supernumerary marker chromosome 4 (sSMS(4)) and infertility. ICGi040-A cells have karyotype 47,XY,+r(4) in 97% of cells and express a set of pluripotent markers, as well as are able to differentiate in vitro into derivatives of all three embryonic germ layers.

Automated summary

The iPSC line ICGi040-A, derived from skin fibroblasts of a male patient with mosaic ring small supernumerary marker chromosome 4 (sSMS(4)) and infertility, has a karyotype of 47,XY,+r(4) in 97% of cells and expresses pluripotent markers, demonstrating the ability to differentiate into derivatives of all three embryonic germ layers in vitro.