期刊
SMALL
卷 18, 期 16, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202106570
关键词
catalase-mimicking catalysis; hypoxia alleviation; magnetic resonance imaging; manganese ferrite nanoparticles; positron emission tomography
类别
资金
- MCIN [PID2019-106139RA-100]
- Ministerio de Economia, Industria y Competitividad (MEIC) [SAF2017-84494-C2-R]
- BBVA Foundation
- La Caixa [PR [18]_BIO_IMG_0008]
- Santander-Universidad Zaragoza Fellowship program [HR18-00052]
- Ramon y Cajal program [RYC-2014-15512]
- Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency
- Ligue contre le Cancer [MDM-2017-0720]
- Region Nouvelle Aquitaine (Projet Nanovect) [CD16, CD17]
- HFSP [RTI2018-099357-B-I00]
- Pro-CNIC Foundation [RGP0016/2018, CIBERFES16/10/00282, RED2018-102576-T]
- Severo Ochoa of Excellence Program
Manganese ferrite nanoparticles have unique properties in bioimaging and catalytic therapies. They have been used as contrast agents in magnetic resonance imaging (MRI) and as catalase-mimicking nanozymes for hypoxia alleviation. A cost-efficient synthetic microwave method has been developed to manufacture ultrasmall manganese ferrite nanoparticles with enhanced bioimaging and catalytic properties. These nanoparticles can be used as multimodal contrast agents in MRI and positron emission tomography (PET), and also have improved catalytic efficiency.
Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used in theranostics as contrast agents in magnetic resonance imaging (MRI), and as catalase-mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance the bioimaging and catalytic properties of these nanomaterials simultaneously. Herein, a cost-efficient synthetic microwave method is developed to manufacture ultrasmall manganese ferrite nanoparticles as advanced multimodal contrast agents in MRI and positron emission tomography (PET), and improved nanozymes. Such a synthetic method allows doping ferrites with Mn in a wide stoichiometric range (MnxFe3-xO4, 0.1 <= x <= 2.4), affording a library of nanoparticles with different magnetic relaxivities and catalytic properties. These tuned magnetic properties give rise to either positive or dual-mode MRI contrast agents. On the other hand, higher levels of Mn doping enhance the catalytic efficiency of the resulting nanozymes. Finally, through their intracellular catalase-mimicking activity, these ultrasmall manganese ferrite nanoparticles induce an unprecedented tumor growth inhibition in a breast cancer murine model. All of these results show the robust characteristics of these nanoparticles for nanobiotechnological applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据