期刊
SMALL
卷 18, 期 36, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202200799
关键词
fluid-aggregated scaffolds; Janus structures; short fibers; wound exudates
类别
资金
- National Natural Science Foundation of China [81772099, 81801928, 32000937]
- Shanghai Municipal Health Commission [20204Y0354]
- China Postdoctoral Science Foundation [2020M681321]
- Shanghai Jiao Tong University Medical and Research Program [ZH2018ZDA04]
- Science and Technology Commission of Shanghai Municipality [19440760400]
- Shanghai Muicipal Key Clinical Specialty [shslczdzk00901]
A Janus electrospun short fiber scaffold has been fabricated, which can aggregate wound exudate and trigger the cascade release of curcumin, thus promoting the healing process of chronic wounds.
Exudate management is critical to improve chronic wound healing. Herein, inspired by a Janus-structured lotus leaf with asymmetric wettability, a Janus electrospun short fiber scaffold is fabricated via electrospinning technologies and short fiber modeling. This scaffold is composed of hydrophilic 2D curcumin-loaded electrospun fiber and hydrophobic 3D short fiber via layer-by-layer assembly and electrostatic interactions which can aggregate the wound exudate by pumping from the hydrophobic layer to the hydrophilic via multiple contact points between hydrophilic and hydrophobic fibers, and simultaneously trigger the cascade release of curcumin in the upper 2D electrospun fiber. The 3D short fiber with high porosity and hydrophobicity can quickly aggregate exudate within 30 s after compounding with hydrophilic 2D electrospun fiber via a spontaneous pump. In vitro experiments show that Janus electrospun short fiber has good biocompatibility, and the cascade release of curcumin can significantly promote the proliferation and migration of fibroblasts. In vivo experiments show that it can trigger cascade release of curcumin by aggregating wound exudate, so as to accelerate wound healing process and promote collagen deposition and vascularization. Hence, this unique biometric Janus scaffold provides an alternative for chronic wound healing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据