Non-Invasive Thermal Therapy for Tissue Engineering and Regenerative Medicine

Owing to the development of nanotechnology and noninvasive treatment, thermal therapy in combination with external stimuli has been applied for tissue engineering and regenerative medicine (TERM), which has attracted more and more attention in recent years. In this review, the recent progress of applying a variety of non-invasive thermal therapeutic modalities for TERM, including photothermal therapy, magnetic thermotherapy, and ultrasound thermotherapy, as well as other thermal therapeutics are discussed. The parameters and conditions that need to be considered and regulated to realize a well-controlled thermal therapy for tissue regeneration are also discussed. Afterwards, the current concerns and challenges of putting thermal therapy into clinical applications are pointed out. At last, perspectives are provided for the future development directions, aiming to providing opportunities and a novel pathway for TERM.

Automated summary

This review discusses the recent progress in applying various non-invasive thermal therapeutic modalities, such as photothermal therapy, magnetic thermotherapy, and ultrasound thermotherapy, for tissue engineering and regenerative medicine (TERM). The parameters and conditions required for well-controlled thermal therapy for tissue regeneration are also discussed. Challenges and concerns regarding the clinical application of thermal therapy are pointed out, and future development directions are provided to offer opportunities and a new pathway for TERM.