期刊
SMALL
卷 18, 期 20, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202200178
关键词
biohazard elimination; microbial safety; nanocatalysis; nanozymes; quasi metal-organic frameworks
类别
资金
- National Natural Science Foundation of China [3217161084]
- Guangzhou Key Laboratory for Intelligent Sensing and Quality Control of Agricultural Products [202102100009]
- Guangdong Provincial Science and Technology Plan Projects [2020A1414010160]
- Guangdong Basic and Applied Basic Research Foundation [2020A1515010936]
- Contemporary International Collaborative Research Centre of Guangdong Province on Food Innovative Processing and Intelligent Control [2019A050519001]
- Common Technical Innovation Team of Guangdong Province on Preservation and Logistics of Agricultural Products [2021KJ145]
This study demonstrates the design of a nanozyme Q-MOFCe0.5 through a hierarchical quasi-MOF scheme, which has the ability to generate sustained reactive oxygen species, effectively killing bacteria and disinfecting wounds.
Metal-organic frameworks (MOFs) are a versatile toolbox for the bioinspired design of nanozymes for antibacterial applications and beyond, however, designing a nanozyme by the hierarchical quasi-MOF scheme remains largely unpracticed. This work exemplifies the preferential structure-activity correlation of a bimetallic quasi-MOF (Q-MOFCe0.5) among three series of MOF-derived peroxidase (POD) mimics. The biomimetic quasi-MOFCe0.5 nanosheets accommodate both oxygen vacancy-coupled multivalent redox cycles and photosensitive energy band layout, benefiting from the hierarchical heterojunction-like 0D/2D interface featuring isolated nodes-derived Ce-O-Cu sites upon the 2D decarboxylated MOF scaffold. These integrated unique merits enable the POD-like Q-MOFCe0.5 to generate sustained reactive oxygen species to effectively eradicate the surface-adhered bacteria under visible light, resulting in significant inactivation of Escherichia coli (99.74 %) and Staphylococcus aureus (99.35%) in vitro, and potent disinfection of skin wounds in vivo in safe and on-demand manners. It is hoped that this work can intensify the interventions of MOF nanozymes against the microbial world.
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