4.6 Review

Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis

期刊

SLEEP MEDICINE REVIEWS
卷 64, 期 -, 页码 -

出版社

W B SAUNDERS CO LTD
DOI: 10.1016/j.smrv.2022.101647

关键词

Sleep deprivation; Depressive disorder; Major; Bipolar disorder; Systematic review; Meta-analysis; Chronotherapy

资金

  1. NIHR (National Institute for Health Research) Research Capability Fund
  2. NIHR Research Professorship [RP-2017-08-ST2-006]
  3. NIHR Oxford Health Biomedical Research Centre [BRC-1215-200 05]
  4. National Institute for Health Research (NIHR) Oxford Cognitive Health Clinical Research Facility
  5. NIHR Oxford and Thames Valley Applied Research Collaboration
  6. NIHR Oxford Biomedical Research Centre [BRC-1215-200 05]

向作者/读者索取更多资源

Sleep deprivation, either alone or in combination with pharmacological treatment, may have potential benefits for people with major depressive episodes. However, the current evidence regarding its clinical effects is conflicting.
Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. The aim of this systematic review and meta-analysis is to assess the clinical effects of sleep deprivation in comparison to any other intervention for the acute and long-term treatment of mood disorders. We searched electronic databases and trial registries (last update: 16th October 2021) for published and unpublished randomised controlled trials recruiting participants with a major depressive episode in unipolar or bipolar affective disorder. The clinical outcomes of interest were the reduction in depressive symptoms at different timepoints and the number of participants experiencing at least one side effect. Overall, 29 trials (1246 participants) were included. We did not find any difference in change in symptoms or all-cause discontinuation between interventions including SD compared to a control of the same intervention except without SD. In the included studies there were no available data for adverse events. Using the most methodologically rigorous approach, we did not find evidence that the addition of sleep deprivation to treatment packages leads to enhanced depressive outcomes. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据