4.3 Article

The association between sleep architecture, quality of life, and hypertension in patients with obstructive sleep apnea

期刊

SLEEP AND BREATHING
卷 27, 期 1, 页码 191-203

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s11325-022-02589-z

关键词

Obstructive sleep apnea; Quality of life; Daytime sleepiness; Hypertension

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This study investigated the association between hypertension and sleep measures, as well as quality of life (QoL), in patients with obstructive sleep apnea (OSA). The results showed that in patients with OSA, nocturnal minimum oxygen saturation was negatively correlated with QoL measures. In patients with OSA and hypertension, sleep duration was negatively correlated with QoL measures. QoL in patients with mild, moderate, and severe OSA was associated with depression and anxiety.
Objective The aim of this study was to investigate the association between hypertension and overnight polysomnography measures of sleep duration, sleep architecture, and quality of life (QoL) in patients with obstructive sleep apnea (OSA). Methods Participants were patients suspected of having OSA with or without hypertension. All patients underwent overnight polysomnography and completed the Epworth Sleepiness Scale (ESS), Self-Rating Anxiety Scale, Self-Rating Depression Scale, and 12-item Short-Form Health Survey. Results Of 128 patients (mean age 46.2 +/- 12.5 years), 53% had hypertension. The average total sleep duration was 344 min (standard deviation 90) or 5.7 h and sleep efficiency was < 70%. There was no significant difference between patients with OSA with/without hypertension in total sleep duration, sleep architecture, anxiety, depression, ESS scores, or QoL. In patients with OSA, nocturnal minimum oxygen saturation was significantly negatively correlated with bodily pain and physical component summary (PCS) scores; mean nocturnal saturation was negatively correlated with bodily pain and social function; anxiety showed a significant negative correlation with role emotional; and depression was significantly negatively correlated with physical function, role physical, general health, role emotional, PCS, and mental component summary (MCS) scores. In the group with OSA and hypertension, N3 duration was negatively correlated with social function, mental health, and MCS scores. Anxiety was significantly negatively correlated with physical function, role physical, vitality, mental health, role emotional, PCS, and MCS scores. Depression was significantly negatively correlated with physical function, role physical, vitality, mental health, role emotional, PCS, and MCS scores. In patients with mild, moderate, and severe OSA, QoL was associated with depression. In mild OSA, PCS was correlated with ESS and anxiety. In moderate OSA, MCS was correlated with apnea-hypopnea index scores. In severe OSA, MCS and PCS were correlated with anxiety. Conclusions There were no significant associations between the presence of hypertension and total sleep duration, sleep architecture, or QoL in patients with OSA. However, hypertension may affect the influencing factors of QoL in patients with OSA. Further cohort studies are needed to confirm these findings.

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