期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 359, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2022.131586
关键词
Wearable sweat sensor; Parkinson's disease; Enzyme immobilization; Noninvasive drug detection; ZIF-8
资金
- National Natural Science Foundation of China [21804007, 21890742]
- SZU Top Ranking Project [86000000210]
- Shenzhen Stability Support Plan [20200806163622001]
- Fundamental Research Funds for the Central Universities [FRF-BY-20-02]
In this study, a simple, wearable, noninvasive, and portable metal-organic framework (MOF)-based electrochemical sensor was developed for monitoring the concentration of levodopa in sweat, which can serve as a proxy for the levels of L-dopa in the body. The sensor showed a wide linear response range, low detection limit, good selectivity, high sensitivity, and stability.
Levodopa (L-dopa) is an effective medication for Parkinson's disease. However, excess intake from overdose or the intake of natural sources of L-dopa can be dangerous, causing, for example, tardive dyskinesia. Therefore, in medicated individuals, it is important to monitor the levels of L-dopa in the body. In this paper, we report a simple, wearable, noninvasive, and portable metal-organic framework (MOF)-based electrochemical sensor with integrated enzymes for monitoring the concentration of levodopa in sweat, which can be used as a proxy for L-dopa levels in the body. Zeolitic imidazolate framework/graphene oxide (ZIF-8/GO) composites were prepared by the in-situ growth of ZIF-8 nanoparticles on the surface of GO, and, subsequently, tyrosinase was loaded onto the composite to yield the sensor. Integration with a wireless electronic circuit enabled communication between the sensor and a smartphone application for continuous analysis. The sensor was found to have a wide linear response range from 1 to 95 mu M, a low limit of detection of 0.45 mu M, satisfactory reproducibility, and excellent selectivity. In addition, the sensor showed high sensitivity and good stability as a result of the anchoring of the enzyme. Thus, the sensor shows promise for continuous, noninvasive point-of-care drug monitoring and management.
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