期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 354, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.131204
关键词
Flexible photoelectrochemical sensor; Unbiased; Sweat glucose; On-body monitoring; High-sensitivity
资金
- National Natural Science Foundation of China [21804032, 22176052]
- Foundation for Creative Research Groups of Hubei Province of China [2020CFA035]
A flexible PEC patch was demonstrated for unbiased and high-performance sweat glucose detection, consisting of an ultrasensitive PEC sensor and a hydrophilic PDMS sweat collector. The sensor offered excellent durability, low detection limit, desirable selectivity, and high storage stability, with feasibility and accuracy validated through human subjects studies. The potential of the unbiased wearable PEC sensor for patient-friendly diabetic diagnosis was confirmed.
Wearable electrochemical sensors have been extensively used for the non-invasive and quantitative on-body detection of biomarkers in sweat. However, the photoelectrochemical (PEC) sensor, which is an evolutionary generation of the electrochemical method and holds higher sensitivity and the ability to unbiased analysis, is rarely applied to construct flexible wearable sweat devices. Herein, we demonstrated a flexible PEC patch comprised of an ultrasensitive PEC sensor and a hydrophilic poly-(dimethylsiloxane) sweat collector for unbiased and high-performance sweat glucose detection. The proposed PEC sensor offered excellent durability against mechanical deformations, low detection limit (22.2 pM), desirable selectivity, and high storage stability. Moreover, the feasibility and accuracy of this wearable glucose sensor patch were validated through human subjects studies, and the obtained sweat glucose test results closely matched with the commercial kit and correlated well with the blood glucose level. Taken together, we could confirm the considerable promise of the unbiased wearable PEC sensor for patient-friendly diabetic diagnosis.
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