期刊
SENSORS
卷 22, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/s22072519
关键词
insecticide; azamethiphos; tris(2,2 '-bipyridine)ruthenium(II); electrogenerated chemiluminescence; inhibitor
资金
- National Natural Science Foundation of China [22004116, hp21874126]
- Chinese Academy of Sciences (CAS)
- Academy of Sciences for the Developing World (TWAS), President's Fellowship Programme
- CAS President's International Fellowship Initiative (PIFI) Postdoctoral fellowship
This study developed a sensitive, low-cost, and rapid electrogenerated chemiluminescence system for the detection of AZA. The practical utility of the sensor was demonstrated in real samples of lake water and wastewater, showing high recoveries.
Azamethiphos (AZA) is an insecticide and neurotoxic agent that causes the inhibition of acetylcholinesterase (AChE). AChE is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. It is worth mentioning that organophosphates and carbamates inhibit AChE. These AChE inhibitors bind to the active site of the enzyme and inactivate it, leading to paralysis and death. Herein, for the first time, we develop a sensitive, low-cost, and rapid electrogenerated chemiluminescence (ECL) system for the detection of AZA. The designed ECL sensor was applied for the highly sensitive detection of AZA with a wide dynamic range (from 0.1 mu M to 1000 mu M) and low detection limit of 0.07 mu M (S/N = 3). The practical utility of the sensor demonstrates high recoveries (96-102%) in real samples of lake water and wastewater.
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