Microbiota-targeted therapies in inflammation resolution

Gut microbiota has been shown to systemically shape the immunological landscape, modulate homeostasis and play a role in both health and disease. Dysbiosis of gut microbiota promotes inflammation and contributes to the pathogenesis of several major disorders in gastrointestinal tract, metabolic, neurological and respiratory diseases. Much effort is now focused on understanding host-microbes interactions and new microbiota-targeted therapies are deeply investigated as a means to restore health or prevent disease. This review details the immunoregulatory role of the gut microbiota in health and disease and discusses the most recent strategies in manipulating individual patient's microbiota for the management and prevention of inflammatory conditions.

Automated summary

The gut microbiota plays a significant role in immune regulation, health, and disease. An imbalance in the gut microbiota can lead to inflammation and the development of various diseases. Current research focuses on understanding the interaction between the host and microbes, and exploring new methods to manipulate the microbiota to restore health and prevent inflammatory conditions.