期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 124, 期 -, 页码 114-126出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2021.05.020
关键词
MiR-1; Immunoregulation; Cancer therapeutics; Chemosensitivity; MiRNAs
资金
- National Institutes of Health (NIH) [R01CA218545, R01CA241752]
- NIH [R01CA247471, R01CA195586, P01 CA217798]
- National Cancer Institute of the NIH [R01CA218545, R01CA247471, P30CA033572, U54CA209978]
The highly conserved miRNA, miR-1, acts as a tumor suppressor by regulating cancer development processes. Its downregulation is observed in multiple cancers, impacting key aspects such as proliferation, invasion, and metastasis.
The process of cancer initiation and development is a dynamic and complex mechanism involving multiple genetic and non-genetic variations. With the development of high throughput techniques like next-generation sequencing, the field of cancer biology extended beyond the protein-coding genes. It brought the functional role of noncoding RNAs into cancer-associated pathways. MicroRNAs (miRNAs) are one such class of noncoding RNAs regulating different cancer development aspects, including progression and metastasis. MicroRNA-1 (miR-1) is a highly conserved miRNA with a functional role in developing skeletal muscle precursor cells and car-diomyocytes and acts as a consistent tumor suppressor gene. In humans, two discrete genes, MIR-1-1 located on 20q13.333 and MIR-1-2 located on 18q11.2 loci encode for a single mature miR-1. Downregulation of miR-1 has been demonstrated in multiple cancers, including lung, breast, liver, prostate, colorectal, pancreatic, medullo-blastoma, and gastric cancer. A vast number of studies have shown that miR-1 affects the hallmarks of cancer like proliferation, invasion and metastasis, apoptosis, angiogenesis, chemosensitization, and immune modulation. The potential therapeutic applications of miR-1 in multiple cancer pathways provide a novel platform for developing anticancer therapies. This review focuses on the different antitumorigenic and therapeutic aspects of miR-1, including how it regulates tumor development and associated immunomodulatory functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据