Bioavailability and trophic magnification of antibiotics in aquatic food webs of Pearl River, China: Influence of physicochemical characteristics and biotransformation

Information on trophodynamics of antibiotics and subsequent relationships to antibiotic metabolism in river ecosystem is still unavailable, limiting the evaluation of their bioaccumulation and trophodynamics in aquatic food webs. In the present study, concentrations and relative abundance of 11 antibiotics were investigated in surface water, sediment and 22 aquatic taxa (e.g., fish, invertebrates and plankton) from Pearl River, South China. The logarithmic bioaccumulation factors (log BAFs) of antibiotics generally showed positive relationships with their log D (pH-adjusted log Kow), implying that their bioaccumulation of ionizable antibiotics depends on it is in an ionized form. Higher BAFs of antibiotics in benthic biota were observed than those in fish, indicating that sediment ingestion was a possible route of antibiotic exposure. The logarithmic biota-sediment accumulation factors (log BSAFs) of benthic biota increased when log D increased from -4.79 to -0.01, but declined thereafter. Trophodynamics of antibiotics was investigated, and intrinsic clearance were measured in liver microsomes of Tilapia zillii (trophic level [TL]: 2.5), Anabas testudineu (TL:3.9), and Coilia grayi (TL: 5.0). Only ciprofloxacin (CFX) showed significant trophic magnification (Trophic Magnification Factor [TMF] = 1.95), and a higher metabolism rate in lower trophic levels suggest that metabolic biotransformation play a significant role in driving biomagnification of antibiotics.

Automated summary

This study investigated the concentrations and abundance of 11 antibiotics in water, sediment, and various aquatic organisms in the Pearl River, South China. The results showed that the bioaccumulation of antibiotics was positively correlated with their ionized form. Sediment ingestion was found to be a potential route of antibiotic exposure, as indicated by higher bioaccumulation in benthic organisms compared to fish. Additionally, only ciprofloxacin exhibited significant trophic magnification, suggesting the importance of metabolic biotransformation in driving the biomagnification of antibiotics.