Hormesis induced by silver iodide, hydrocarbons, microplastics, pesticides, and pharmaceuticals: Implications for agroforestry ecosystems health

Increasing amounts of silver iodide (AgI) in the environment are expected because of the recent massive expansion of weather modification programs. Concurrently, pharmaceuticals, microplastics, hydrocarbons, and pesticides in terrestrial ecosystems continue contaminating forests and agroforests. Our review supports that AgI induces hormesis, a biphasic dose response characterized by often beneficial low-dose responses and toxic high-dose effects, which adds to the evidence for pharmaceuticals, microplastics, hydrocarbons, and pesticides induced hormesis in numerous species. Doses smaller than the no-observed-adverse-effect-level (NOAEL) positively affect defense physiology, growth, biomass, yields, survival, lifespan, and reproduction. They also lead to negative or undesirable outcomes, including stimulation of pathogenic microbes, pest insects, and weeds with enhanced resistance to drugs and potential negative multi-or trans-generational effects. Such sub-NOAEL effects perplex terrestrial ecosystems managements and may compromise combating outbreaks of disease vectors that can threaten not only forest and agroforestry health but also sensitive human subpopulations living in remote forested areas.

Automated summary

The increasing presence of substances such as silver iodide in the environment due to weather modification programs and human activities can induce hormesis, which has both beneficial and toxic effects depending on the dosage. Lower doses of these substances can enhance defense physiology, growth, and reproduction, but also stimulate pathogenic microbes and pesticide-resistant pests.