期刊
CANCER GENE THERAPY
卷 22, 期 7, 页码 344-350出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cgt.2015.26
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资金
- National Cancer Institute grant [CA132971, CA142669]
- Ministry of Education, Science and Culture, Japan
- Ministry of Health and Welfare, Japan
- Grants-in-Aid for Scientific Research [25293283] Funding Source: KAKEN
Precise fluorescence-guided surgery (FGS) for pancreatic canter has the potential to greatly improve the outcome in this recalcitrant disease. To achieve this goal, we have used genetic reporters to-color code cancer and stroma cells in a patient-derived orthotopic xenograft (PDOX) model. The telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 was used to label the cancer cells of a pancreatic cancer PDOX. The PDOX was previously grown in a red fluorescent protein (RFP) transgenic Mouse that stably labeled the PDOX stroma cells bright red. The color-coded PDOX Model enabled FGS to to completely resect the pancreatic tumors including stroma. Dual-colored FGS significantly prevented local recurrence; which bright-light surgery or single-color FGS could not. FGS, with color-coded canter and stroma cells has important potential for improving the outcome of recalcitrant-cancer surgery.
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