期刊
SCIENCE
卷 376, 期 6596, 页码 1006-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abm1703
关键词
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资金
- National Institutes of Health [1K99HL155844-01A1, R01-HL141470, R01 HL140061, R01 HL125881, KL2TR001424, F30HL157066, 5K99-HL148523-02]
- Ministry of Health & Welfare, Republic of Korea (Korea Health Industry Development Institute) [HI19C1348]
- Leducq Foundation project RHYTHM
- American Heart Association [18SFRN34110170]
- American Heart Association Predoctoral Fellowship [19PRE34380781]
- National Science Foundation [1842165]
- Ford Foundation Predoctoral Fellowship
- Chan Zuckerberg Initiative DAF [2020-225578]
- Silicon Valley Community Foundation
- Direct For Education and Human Resources
- Division Of Graduate Education [1842165] Funding Source: National Science Foundation
This study presents a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden.
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.
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