期刊
SCIENCE
卷 376, 期 6590, 页码 266-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abf7052
关键词
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资金
- Novartis Research Foundation
- European Research Council (ERC) under the European Union [669582, 803870]
- National Center of Competences in Research: SYNAPSY-The Synaptic Bases of Mental Diseases (Swiss National Science Foundation SNSF) [51NF40-158776]
- SNSF [PP00P3_170672, 310030B_170268]
- Brain & Behavior Research Foundation [23593]
- Synapsis Foundation-Alzheimer Research Switzerland ARS [2018-CDA02]
- Fondazione HED ALBIREO
- European Molecular Biology Organization [EMBO-ALTF-233-2020]
- European Research Council (ERC) [803870, 669582] Funding Source: European Research Council (ERC)
- Swiss National Science Foundation (SNF) [310030B_170268, PP00P3_170672] Funding Source: Swiss National Science Foundation (SNF)
This study reveals the functional and plastic properties of active dendrites in behaving animals and the differential plasticity between dendrites and somas induced by fear conditioning.
Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. Activity-dependent plasticity of synaptic input is a major underlying cellular process. Although we have a detailed understanding of synaptic and dendritic plasticity in vitro, little is known about the functional and plastic properties of active dendrites in behaving animals. Using deep brain two-photon Ca2+ imaging, we investigated how sensory responses in amygdala principal neurons develop upon classical fear conditioning, a form of associative learning. Fear conditioning induced differential plasticity in dendrites and somas regulated by compartment-specific inhibition. Our results indicate that learning-induced plasticity can be uncoupled between soma and dendrites, reflecting distinct synaptic and microcircuit-level mechanisms that increase the computational capacity of amygdala circuits.
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