期刊
SCIENCE
卷 376, 期 6595, 页码 817-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abn6204
关键词
-
资金
- Fonds de la Recherche Scientifique (FRS) Fonds National de la Recherche Scientifique (FNRS)
- Excellence of Science [0019118F-RG36]
- Fonds Leon Fredericq
- Fondation Medicale Reine Elisabeth
- Fondation Simone et Pierre Clerdent
- Belgian Science Policy (IAP-VII network) [P7/20]
- ERANET Neuron (STEM-MCD) [2010126]
During embryogenesis, vOPCs and cortical interneurons interact and occupy mutually exclusive territories in the forebrain. First-wave vOPCs play a crucial role in steering the migration of cortical interneurons away from blood vessels, allowing them to reach their proper cortical territories.
In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. By coupling histological analysis of genetic models with live imaging, we show that although they are both attracted by the chemokine Cxcl12, vOPCs and cortical interneurons occupy mutually exclusive forebrain territories enriched in this chemokine. Moreover, first-wave vOPC depletion selectively disrupts the migration and distribution of cortical interneurons. At the cellular level, we found that by promoting unidirectional contact repulsion, first-wave vOPCs steered the migration of cortical interneurons away from the blood vessels to which they were both attracted, thereby allowing interneurons to reach their proper cortical territories.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据