期刊
SCIENCE
卷 375, 期 6585, 页码 1159-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abj5170
关键词
-
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)/Japan Society for the Promotion of Science (JSPS) KAKENHI [JP18H05420, JP18H02417, JP17K15110, JP18J40041]
This study developed a new protein and DNA-based system for intracellular transport, which can be used for multiplexed cargo transport and control on DNA nanotubes. This technology is expected to have significant applications in the future.
Intracellular transport is the basis of microscale logistics within cells and is powered by biomolecular motors. Mimicking transport for in vitro applications has been widely studied; however, the inflexibility in track design and control has hindered practical applications. Here, we developed protein-based motors that move on DNA nanotubes by combining a biomolecular motor dynein and DNA binding proteins. The new motors and DNAbased nanoarchitectures enabled us to arrange the binding sites on the track, locally control the direction of movement, and achieve multiplexed cargo transport by different motors. The integration of these technologies realized microscale cargo sorters and integrators that automatically transport molecules as programmed in DNA sequences on a branched DNA nanotube. Our system should provide a versatile, controllable platform for future applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据