相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。UCSF ChimeraX: Structure visualization for researchers, educators, and developers
Eric F. Pettersen et al.
PROTEIN SCIENCE (2021)
Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat
David S. Mathiesen et al.
FRONTIERS IN ENDOCRINOLOGY (2021)
AM833 is a novel agonist of calcitonin family G protein-coupled receptors: pharmacological comparison to six selective and non-selective agonists
Madeleine M. Fletcher et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)
Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management: a randomised, controlled, phase 1b trial
Lone B. Enebo et al.
LANCET (2021)
Development of Cagrilintide, a Long-Acting Amylin Analogue
Thomas Kruse et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM
Ali Punjani et al.
JOURNAL OF STRUCTURAL BIOLOGY (2021)
Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics
Sang-Min Lee et al.
JOURNAL OF MOLECULAR BIOLOGY (2020)
Dose Frequency Optimization of the Dual Amylin and Calcitonin Receptor Agonist KBP-088: Long-Lasting Improvement in Food Preference and Body Weight Loss
Anna Thorso Larsen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)
Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation
Yi-Lynn Liang et al.
MOLECULAR CELL (2020)
Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases
Hannah Louise Zakariassen et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2020)
The Calcitonin Receptor Plays a Major Role in Glucose Regulation as a Function of Dual Amylin and Calcitonin Receptor Agonist Therapy
Anna Thorso Larsen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)
Molecular interaction of an antagonistic amylin analog with the extracellular domain of receptor activity-modifying protein 2 assessed by fluorescence polarization
Sangmin Lee et al.
BIOPHYSICAL CHEMISTRY (2020)
Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors
Michael L. Garelja et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins
Yi-Lynn Liang et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)
The Dual Amylin and Calcitonin Receptor Agonist KBP-088 Induces Weight Loss and Improves Insulin Sensitivity Superior to Chronic Amylin Therapy
Anna Thorso Larsen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)
Pharmacological Characterization and Investigation of N-Terminal Loop Amino Acids of Adrenomedullin 2 That Are Important for Receptor Activation
Hala Musa et al.
BIOCHEMISTRY (2019)
The Molecular Control of Calcitonin Receptor Signaling
Emma dal Maso et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2019)
SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM
Thorsten Wagner et al.
COMMUNICATIONS BIOLOGY (2019)
MolProbity: More and better reference data for improved all-atom structure validation
Christopher J. Williams et al.
PROTEIN SCIENCE (2018)
Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy
Emma Dal Maso et al.
BIOCHEMICAL PHARMACOLOGY (2018)
Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION
Takanori Nakane et al.
ELIFE (2018)
PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Hsin-Yung Yen et al.
NATURE (2018)
Cryo-EM structure of the active, G(s)- protein complexed, human CGRP receptor
Yi-Lynn Liang et al.
NATURE (2018)
New tools for automated high-resolution cryo-EM structure determination in RELION-3
Jasenko Zivanov et al.
ELIFE (2018)
Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin
Rebekah L. Bower et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2018)
Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination
Yi-Lynn Liang et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2018)
Phase-plate cryo-EM structure of a class B GPCR-G-protein complex
Yi-Lynn Liang et al.
NATURE (2017)
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
Shawn Q. Zheng et al.
NATURE METHODS (2017)
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
Ali Punjani et al.
NATURE METHODS (2017)
Optimization of tolerability and efficacy of the novel dual amylin and calcitonin receptor agonist KBP-089 through dose escalation and combination with a GLP-1 analog
Sofie Gydesen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2017)
Does salmon calcitonin cause cancer? A review and meta-analysis
G. Wells et al.
OSTEOPOROSIS INTERNATIONAL (2016)
KBP-088, a novel DACRA with prolonged receptor activation, is superior to davalintide in terms of efficacy on body weight
Sofie Gydesen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2016)
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy
Sebastian George Barton Furness et al.
CELL (2016)
Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography
Eva Johansson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Calcitonin and Amylin Receptor Peptide Interaction Mechanisms INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS
Sang-Min Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Gctf: Real-time CTF determination and correction
Kai Zhang
JOURNAL OF STRUCTURAL BIOLOGY (2016)
An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology
Joseph J. Gingell et al.
CELL DISCOVERY (2016)
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor
Jason M. Booe et al.
MOLECULAR CELL (2015)
Amylin: Pharmacology, Physiology, and Clinical Potential
Debbie L. Hay et al.
PHARMACOLOGICAL REVIEWS (2015)
A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats
Kim V. Andreassen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)
Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation
Debbie L. Hay et al.
BRITISH JOURNAL OF PHARMACOLOGY (2014)
Activity of Pramlintide, Rat and Human Amylin but not Aβ1-42 at Human Amylin Receptors
Joseph J. Gingell et al.
ENDOCRINOLOGY (2014)
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
Denise Wootten et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Cryo-Electron Microscopy Modeling by the Molecular Dynamics Flexible Fitting Method
Kwok-Yan Chan et al.
BIOPOLYMERS (2012)
A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: The oral calcitonin in postmenopausal osteoporosis (ORACAL) trial
Neil Binkley et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2012)
A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats
M. Feigh et al.
DIABETES OBESITY & METABOLISM (2011)
Glucoregulatory effects and prolonged duration of action of davalintide: a novel amylinomimetic peptide
C. M. Mack et al.
DIABETES OBESITY & METABOLISM (2011)
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
Roman A. Laskowski et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
The role of amylin in the control of energy homeostasis
Thomas A. Lutz
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2010)
Enhanced Weight Loss Following Coadministration of Pramlintide With Sibutramine or Phentermine in a Multicenter Trial
Louis J. Aronne et al.
OBESITY (2010)
A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor
Joseph J. Gingell et al.
PEPTIDES (2010)
Dynamic α-Helix Structure of Micelle-bound Human Amylin
Sharadrao M. Patil et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors
Maria Morfis et al.
ENDOCRINOLOGY (2008)
Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function
Tao Qi et al.
MOLECULAR PHARMACOLOGY (2008)
Effects of intermittent intraperitoneal infusion of salmon calcitonin on food intake and adiposity in obese rats
Prasanth K. Chelikani et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: A phase 2, randomized, placebo-controlled, dose-escalation study
Louis Aronne et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)
A critical role for the short intracellular C terminus in receptor activity-modifying protein function
Madhara Udawela et al.
MOLECULAR PHARMACOLOGY (2006)
Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors
Madhara Udawela et al.
MOLECULAR PHARMACOLOGY (2006)
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes
DL Hay et al.
MOLECULAR PHARMACOLOGY (2005)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Identification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptors
JM Hilton et al.
JOURNAL OF ENDOCRINOLOGY (2000)